Devices, systems and methods for determining depth of interaction in positron emission tomography detectors

ABSTRACT

The present disclosure relates to devices, systems and methods for determining a position of a photon gamma interaction in a PET detector. The PET detector may include a crystal array and a single-end read-out structure. The single-end read-out structure may include a photon-sensor array optically coupled with the crystal array. The crystal array may include a plurality of crystal elements arranged along a first direction and a second direction. The crystal elements may form a plurality of crystal groups along the first direction. The PET detector may further include a plurality of optical separators of the same or different lengths configured to control light transmission in the PET detector. The position of the photon gamma interaction in a crystal group may be determined based on output information of the photon-sensor array optically coupled with the crystal group.

CROSS-REFERENCE TO RELATED APPLICATION

This application claims priority to Chinese Patent Application No. 201810027134.0, filed on Jan. 11, 2018, the content of which is expressly incorporated herein by reference in their entireties.

TECHNICAL FIELD

The present disclosure generally relates to Positron Emission Tomography (PET), and more specifically, to systems and methods for determining a depth of interaction (DOI) in PET detectors.

BACKGROUND

PET is an imaging technique that produces a three-dimensional image of functional processes in an object or a portion thereof. Typically, biologically active molecules carrying radioactive tracer molecules may be introduced into the object. The tracer may undergo positron emission decay and emit a positron. The positron may annihilate with an electron, generating a pair of annihilation photons (e.g., gamma photons) that move in approximately opposite directions. The annihilation photons may be absorbed by a plurality of crystal elements (e.g., arranged in the form of one or more rings) that create bursts of optical photons (e.g., visible light photons) that, in turn, may be detected by photodetectors. Then the three-dimensional image of the object may be generated based on coincident photon detections. Because pairs of detected annihilation photons may travel along nearly straight lines (referred to as lines of response (LOR)), the tracer location may be determined by identifying LORs.

In conventional systems, a PET scanner exhibits a progressive reduction in spatial resolution with increased distance away from the center of its field of view (FOV). This resolution loss is at least partly caused by an uncertainty in assigning an LOR to a detected coincident event. The uncertainty of LOR assignment may be relatively smaller for a pair of detector modules located near the scanner's central axis (i.e., an axis along an axial direction of the scanner passing through the center of the FOV) than that located far from the central axis. Also, the uncertainty of LOR assignment may be relatively smaller for a pair of detector modules located closer to each other along the axial direction of the scanner than a pair of detector modules located far away from each other. For example, as illustrated in FIG. 2a , a pair of detector modules 201 and 202 is located nearer to the scanner's center axis than a pair of detector modules 203 and 204. As illustrated in FIG. 2b , the distance between the detector modules 201 and 202 along the axial direction of the scanner is smaller than that between a pair of detector modules 202 and 205. The dotted lines A and B define a range of possible LORs assigned to the detector modules 201 and 202, C and D define a range of possible LORs assigned to the detector modules 203 and 204, and E and F define a range of possible LORs assigned to the detector modules 202 and 205. The difference Δr1 between A and B is smaller than the difference Δr2 between C and D, suggesting a relative smaller resolution loss in detector modules 201 and 202 than detector modules 203 and 204. Similarly, the difference Δr1 is smaller than the difference Δr3 between E and F, suggesting a relative smaller resolution loss in detector modules 201 and 202 than detector modules 202 and 205.

Thus, in order to improve imaging resolution, it is desirable to determine the position or depth of photon gamma interactions occurred within a PET detector. PET imaging systems that provide depth of interaction (DOI) information can assign LORs to coincident events more accurately, thereby resulting in a more uniform resolution throughout the FOV. A plurality of techniques for extracting DOI information from a PET detector has been proposed. A possible way is to optically couple photon-sensors to both ends of a crystal element of a PET detector. For example, as illustrated in FIG. 3a , a photon-sensor 301 a and a photon-sensor 301 b are optically coupled to two ends of a crystal element 302, respectively. The DOI information of a photon gamma interaction (e.g., a photon gamma interaction 1) within the crystal element 302 may be determined based on the ratio of output energies from the photon-sensors 301 a and 301 b.

Another exemplary way employs a photon-sensor array coupled to a monolithic crystal. For example, as illustrated in FIG. 3b , a photon-sensor array 303 including a plurality of photon-sensors 301 c is optically coupled to a crystal element 304. The DOI information of photon gamma interaction (e.g., a photon gamma interaction 2 or 3) may be determined based on a distribution of outputs of the photon-sensors 301 c. For example, when a photon gamma interaction excites one or more photons that are detected by more photon-sensors 301 c, it may occur at a position farther away from the photon-sensor array 303.

Yet another exemplary way is based on multilayer crystals optically coupled with a photon-sensor array, and to determine the DOI information based on the characteristics of signals detected by the photon-sensor array. For example, as shown in FIG. 3c , a PET detector includes a first crystal layer 305, a second crystal layer 306, and a photon-sensor array 307 optically coupled to the second crystal layer 306. The properties of the crystals in different layers may be different. The above mentioned techniques may be applied in DOI determination, however, most of them rely on additional detector electronics, thereby requiring considerably more complicated hardware and possibly introducing other issues. Therefore, it is desirable to provide devices, systems, and methods for determining DOI in PET systems efficiently and accurately.

SUMMARY

According to an aspect of the present disclosure, a PET detector may include a crystal array and a single-end read-out structure. The crystal array may include a plurality of crystal elements. The plurality of crystal elements may be arranged along a first direction and a second direction so as to define a plurality of crystal groups along the first direction. Each of the plurality of crystal groups may include at least two crystal elements of the plurality of crystal elements. Each of the plurality of crystal elements may include a first end and a second end and may extend along a third direction from the first end to the second end. A photon-sensor array optically coupled with the crystal array. At least one pair of neighboring crystal groups of the plurality of crystal groups may include a first optical separator and a second optical separator. The first optical separator of a first length may locate between the crystal groups of the at least one pair of neighboring crystal groups, the first length being along the third direction. The second optical separator of a second length may locate between two neighboring crystal elements of a crystal group of the at least one pair of neighboring crystal groups, the second length being along the third direction. The first length of the first optical separator may be equal to or greater than the second length of the second optical separator.

In some embodiments, the photon-sensor array forms a single-end read-out structure, and the photon-sensor array may include a plurality of photon-sensors configured to receive photons emitted from the first ends of the plurality of crystal elements.

In some embodiments, each photon-sensor of the photon-sensor array may be optically coupled with one or more crystal elements of the plurality of crystal elements.

In some embodiments, the detector may include one or more third optical separators. Each of the one or more third optical separators may locate between two neighboring crystal elements along the second direction.

In some embodiments, at least one of the first optical separator, the second optical separator, or the one or more third optical separators may include at least one of a reflective film, a reflective foil, or a reflective coating.

In some embodiments, the first optical separator extends from the first end of one of the plurality of crystal elements to the second end of the one of the plurality of crystal elements.

In some embodiments, the second length of the second optical separator may be equal to or greater than a half of a length of at least one of the two neighboring crystal elements between which the second optical separator is located, the length of the crystal element being along the third direction.

In some embodiments, at least one of the first optical separator or second optical separator may extend, along the third direction, from the first end of at least one of two neighboring crystal elements between which the at least one of the first or second optical separator is located.

In some embodiments, at least one crystal group of the plurality of crystal groups, the second ends of the at least two crystal elements may be integrated into a single end.

In some embodiments, the first optical separator extends from the first end of one of the plurality of crystal elements to the second end of the one of the plurality of crystal elements.

According to another aspect of the present disclosure, a computer-implemented method may include one or more of the following operations performed by at least one processor. The method may include obtaining output information of at least two photon-sensors. The at least two photon-sensors may be optically coupled with one crystal group of a PET detector. The output information may correspond to a photon gamma interaction in the crystal group. The method may also include determining, based on the output information, a position of the photon gamma interaction within the crystal group.

In some embodiments, the method may also include identifying, in the crystal group, a target crystal element in which the photon gamma interaction occurs based on the output information.

In some embodiments, the method may also include determining a depth of the photon gamma interaction within the target crystal element based on the output information.

In some embodiments, the output information of the at least two photon-sensors may include an energy detected by each of the at least two photon-sensors. The method may also include determining a total energy detected by the at least two photon-sensors based on the energy detected by each of the at least two photon-sensors. The method may further include determining the position of the photon gamma interaction within the crystal group based on the energy detected by each of the at least two photon-sensors and the total energy.

According to another aspect of the present disclosure, a computer-implemented method may include one or more of the following operations performed by at least one processor. The method may include obtaining output information of a plurality of photon-sensor groups. Each of the plurality of photon-sensor groups may include at least two photon-sensors and being optically coupled to a crystal group of a PET detector. The output information may correspond to a photon gamma interaction in the plurality of crystal groups. The method may also include determining a plurality of candidate positions of the photon gamma interaction in the plurality of crystal groups based on the output information. Each of the plurality of candidate positions may correspond to one of the plurality of crystal groups and may include a candidate depth of the photon gamma interaction within the corresponding crystal group. The method may further include determining that an inter crystal scatter (ICS) occurs within the plurality of crystal groups based on the output information. The method may further include designating, among the plurality of candidate positions, the candidate position with the smallest candidate depth as a position of the photon gamma interaction.

According to still another aspect of the present disclosure, a PET detector may include a plurality of detector rings arranged along an axial direction of the detector. Each of the plurality of detector rings may include a plurality of crystal elements. The plurality of crystal elements may define a plurality of crystal groups arranged along the axial direction of the detector. Each of the plurality of crystal groups may include at least two crystal elements that belong to at least two individual detector rings. Each of the plurality of crystal elements may include a proximal end and a distal end with respect to a central axis of the detector and may extend along an extension direction from its distal end to its proximal end. At least a pair of neighboring crystal groups of the plurality of crystal groups may include a first optical separator and a second optical separator. The first optical separator of a first length may locate between the crystal groups of the at least one pair of neighboring crystal groups, the first length being along the extension direction of at least one crystal element of the at least one pair of neighboring crystal groups. The second optical separator of a second length may locate between two neighboring crystal elements of a crystal group of the at least one pair of neighboring crystal groups, the second length being along the extension direction of the at least one crystal element of the at least one pair of neighboring crystal groups. The first length of the first optical separator may be equal to or greater than the second length of the second optical separator.

In some embodiments, at least one detector ring may include a plurality of photon-sensors configured to receive photons emitted from respective distal ends of the plurality of crystal elements of the at least one detector ring.

In some embodiments, each photon-sensor of the plurality of photon-sensors may be optically coupled with one or more crystal elements of the at least one detector ring.

In some embodiments, at least one detector ring may include a third optical separator located between each pair of neighboring crystal elements of the at least one detector ring.

According to still another aspect of the present disclosure, a computer-implemented method may include one or more of the following operations performed by at least one processor. The method may include obtaining output information of at least two photon-sensors. Each photon-sensor of the at least two photon-sensors may be optically coupled with one or more of crystal elements that belong to a crystal group of a PET detector. The output information may correspond to a photon gamma interaction in the crystal group.

In some embodiments, the method may also include determining, based on the output information, a position of the photon gamma interaction within the crystal group.

In some embodiments, the method may also include identifying, among the crystal elements optically coupled to the at least two photon-sensors, a target crystal element where the photon gamma interaction occurs based on the output information.

In some embodiments, the method may also include determining a depth of the photon gamma interaction within the target crystal element based on the output information.

In some embodiments, the output information of the at least two photon-sensors may include an energy detected by each of the at least two photon-sensors, the method may also include determining a total energy detected by the at least two photon-sensors based on the energy detected by each of the at least two photon-sensors. The method may further include determining the position of the photon gamma interaction within the crystal group based on the energy detected by each of the at least two photon-sensors and the total energy.

According to still another aspect of the present disclosure, a PET detector may include a crystal array and a single-end read-out structure. The crystal array may include a plurality of crystal elements, the plurality of crystal elements being arranged along a first direction and a second direction so as to define a plurality of crystal groups along the first direction. Each of the plurality of crystal groups may include at least two crystal elements of the plurality of crystal elements. Each of the plurality of crystal elements may include a first end and a second end and may extend along a third direction from the first end to the second end. The single-end read-out structure may include a photon-sensor array optically coupled with the crystal array. At least one crystal group of the plurality of crystal groups may include an optical window configured to allow a light transmission between the at least two crystal elements of the at least one crystal group, so that a photon excited by an photon gamma interaction in a first crystal element of the at least one crystal group can travel into a second crystal element of the at least one crystal group through the second end of the first crystal element, the optical window, and the second end of the second crystal element.

In some embodiments, the optical window of the at least one crystal group may include an optical separator and a light transmission medium. For each of the at least two crystal elements of the at least one crystal group, the optical separator may mount on each side surface of the crystal element that faces a neighboring crystal element of the crystal element along the first direction. A length of the optical separator may equal to a length of at least one of the crystal element or the neighboring crystal element, the length of the optical separator and the length of the at least one of the crystal element or the neighboring crystal element being along the third direction. The light transmission medium may cover the second ends of the at least two crystal elements of the at least one crystal group. Each side surface of the light transmission medium that faces a neighboring crystal group of the at least one crystal group may be coated with a light reflective material.

In some embodiments, the light transmission medium may be glass.

In some embodiments, the photon-sensor array may include a plurality of photon-sensors configured to receive photons emitted from the first ends of the plurality of crystal elements.

Additional features will be set forth in part in the description which follows, and in part will become apparent to those skilled in the art upon examination of the following and the accompanying drawings or may be learned by production or operation of the examples. The features of the present disclosure may be realized and attained by practice or use of various aspects of the methodologies, instrumentalities and combinations set forth in the detailed examples discussed below.

BRIEF DESCRIPTION OF THE DRAWINGS

The present disclosure is further described in terms of exemplary embodiments. These exemplary embodiments are described in detail with reference to the drawings. These embodiments are non-limiting exemplary embodiments, in which like reference numerals represent similar structures throughout the several views of the drawings, and wherein:

FIG. 1 is a schematic diagram illustrating an exemplary imaging system according to some embodiments of the present disclosure;

FIG. 2a is a schematic diagram illustrating a radial cross section of an exemplary PET imaging device according to some embodiments of the present disclosure;

FIG. 2b is schematic diagram illustrating an axial cross section of an exemplary PET imaging device according to some embodiments of the present disclosure;

FIG. 3a is a schematic diagram illustrating an exemplary detector according to some embodiments of the present disclosure;

FIG. 3b is a schematic diagram illustrating an exemplary detector according to some embodiments of the present disclosure;

FIG. 3c is a schematic diagram illustrating an exemplary detector according to some embodiments of the present disclosure;

FIG. 4 is a schematic diagram illustrating an exemplary detector according to some embodiments of the present disclosure;

FIG. 5 is a schematic diagram illustrating a perspective view of an exemplary crystal group according to some embodiments of the present disclosure;

FIG. 6a is a schematic diagram illustrating exemplary photon gamma interactions occurred in an exemplary crystal group according to some embodiments of the present disclosure;

FIG. 6b is a schematic diagram illustrating exemplary photon gamma interactions occurred in an exemplary crystal group according to some embodiments of the present disclosure;

FIG. 7 is a schematic diagram illustrating an exemplary crystal group according to some embodiments of the present disclosure;

FIG. 8a is a schematic diagram illustrating an exemplary detector according to some embodiments of the present disclosure;

FIG. 8b is a schematic diagram illustrating a perspective view of an exemplary crystal group according to some embodiments of the present disclosure;

FIG. 9a is a schematic diagram illustrating exemplary photon gamma interactions occurred in an exemplary crystal group according to some embodiments of the present disclosure;

FIG. 9b is a schematic diagram illustrating exemplary photon gamma interactions occurred in an exemplary crystal group according to some embodiments of the present disclosure;

FIG. 10a is a schematic diagram illustrating a top view of an exemplary detector according to some embodiments of the present disclosure;

FIG. 10b is a schematic diagram illustrating a top view of an exemplary detector according to some embodiments of the present disclosure;

FIG. 11a is a schematic diagram illustrating an exemplary detector according to some embodiments of the present disclosure;

FIG. 11b is a schematic diagram illustrating an exemplary detector according to some embodiments of the present disclosure;

FIG. 12a is a schematic diagram illustrating an exemplary inter-crystal penetration phenomenon according to some embodiments of the present disclosure;

FIG. 12b is a schematic diagram illustrating an exemplary inter-crystal scatter (ICS) phenomenon according to some embodiments of the present disclosure;

FIG. 13 is a schematic diagram illustrating an exemplary ICS phenomenon in an exemplary crystal array according to some embodiments of the present disclosure;

FIG. 14a is a schematic diagram illustrating an exemplary detector according to some embodiments of the present disclosure;

FIG. 14b is a schematic diagram illustrating an exemplary detector according to some embodiments of the present disclosure;

FIG. 15 is a block diagram illustrating an exemplary computing device according to some embodiments of the present disclosure;

FIG. 16 is a flowchart illustrating an exemplary process for determining the position of a photon gamma interaction in a crystal group according to some embodiments of the present disclosure; and

FIG. 17 is a flowchart illustrating an exemplary process for determining the position of a photon gamma interaction according to some embodiments of the present disclosure.

DETAILED DESCRIPTION

In the following detailed description, numerous specific details are set forth by way of examples in order to provide a thorough understanding of the relevant disclosure. However, it should be apparent to those skilled in the art that the present disclosure may be practiced without such details. In other instances, well-known methods, procedures, systems, components, and/or circuitry have been described at a relatively high-level, without detail, in order to avoid unnecessarily obscuring aspects of the present disclosure. Various modifications to the disclosed embodiments will be readily apparent to those skilled in the art, and the general principles defined herein may be applied to other embodiments and applications without departing from the spirit and scope of the present disclosure. Thus, the present disclosure is not limited to the embodiments shown, but to be accorded the widest scope consistent with the claims.

The terminology used herein is for the purpose of describing particular embodiments only and is not intended to be limiting of example embodiments of the invention. As used herein, the singular forms “a,” “an,” and “the,” are intended to include the plural forms as well, unless the context clearly indicates otherwise. As used herein, the terms “and/or” and “at least one of” include any and all combinations of one or more of the associated listed items. It will be further understood that the terms “comprises,” “comprising,” “includes,” and/or “including,” when used herein, specify the presence of stated features, integers, steps, operations, elements, and/or components, but do not preclude the presence or addition of one or more other features, integers, steps, operations, elements, components, and/or groups thereof. Also, the term “exemplary” is intended to refer to an example or illustration.

It will be understood that the terms “system,” “engine,” “unit,” “module,” and/or “block” used herein are one method to distinguish different components, elements, parts, sections or assembly of different levels in ascending order. However, the terms may be displaced by other expression if they achieve the same purpose.

Generally, the word “module,” “unit,” or “block,” as used herein, refers to logic embodied in hardware or firmware, or to a collection of software instructions. A module, a unit, or a block described herein may be implemented as software and/or hardware and may be stored in any type of non-transitory computer-readable medium or other storage device. In some embodiments, a software module/unit/block may be compiled and linked into an executable program. It will be appreciated that software modules can be callable from other modules/units/blocks or from themselves, and/or may be invoked in response to detected events or interrupts. Software modules/units/blocks configured for execution on computing devices may be provided on a computer-readable medium, such as a compact disc, a digital video disc, a flash drive, a magnetic disc, or any other tangible medium, or as a digital download (and can be originally stored in a compressed or installable format that needs installation, decompression, or decryption prior to execution). Such software code may be stored, partially or fully, on a storage device of the executing computing device, for execution by the computing device. Software instructions may be embedded in a firmware, such as an EPROM. It will be further appreciated that hardware modules/units/blocks may be included in connected logic components, such as gates and flip-flops, and/or can be included of programmable units, such as programmable gate arrays or processors. The modules/units/blocks or computing device functionality described herein may be implemented as software modules/units/blocks, but may be represented in hardware or firmware. In general, the modules/units/blocks described herein refer to logical modules/units/blocks that may be combined with other modules/units/blocks or divided into sub-modules/sub-units/sub-blocks despite their physical organization or storage. The description may be applicable to a system, an engine, or a portion thereof.

It will be understood that the terms “ring,” “layer,” “element,” “group,” etc., when used in this disclosure, refer to one or more parts with one or more specific purposes. However, a structure that may perform a same or similar function compared to a part exemplified above or referred to elsewhere in the present disclosure may be named differently from the present disclosure.

It will be understood that, although the terms “first,” “second,” “third,” etc., may be used herein to describe various elements, these elements should not be limited by these terms. These terms are only used to distinguish one element from another. For example, a first element could be termed a second element, and, similarly, a second element could be termed a first element, without departing from the scope of example embodiments of the present invention.

Spatial and functional relationships between elements (for example, between crystal elements) are described using various terms, including “connected,” “engaged,” “interfaced,” and “coupled.” Unless explicitly described as being “direct,” when a relationship between first and second elements is described in the present disclosure, that relationship includes a direct relationship where no other intervening elements are present between the first and second elements, and also an indirect relationship where one or more intervening elements are present (either spatially or functionally) between the first and second elements. In contrast, when an element is referred to as being “directly” connected, engaged, interfaced, or coupled to another element, there are no intervening elements present. Other words used to describe the relationship between elements should be interpreted in a like fashion (e.g., “between,” versus “directly between,” “adjacent,” versus “directly adjacent,” etc.).

These and other features, and characteristics of the present disclosure, as well as the methods of operation and functions of the related elements of structure and the combination of parts and economies of manufacture, may become more apparent upon consideration of the following description with reference to the accompanying drawings, all of which form a part of this disclosure. It is to be expressly understood, however, that the drawings are for the purpose of illustration and description only and are not intended to limit the scope of the present disclosure. It is understood that the drawings are not to scale.

For illustration purposes, the following description is provided to help better understanding an imaging process. It is understood that this is not intended to limit the scope of the present disclosure. For persons having ordinary skills in the art, a certain amount of variations, changes and/or modifications may be deducted under guidance of the present disclosure. Those variations, changes and/or modifications do not depart from the scope of the present disclosure.

The present disclosure relates to devices, systems and methods for determining a position of a photon gamma interaction in a PET detector. In some embodiments, the PET detector may include a crystal array and a photon-sensor array optically coupled with the crystal array. The crystal array may include a plurality of crystal elements arranged along a first direction and a second direction, and the photon-sensor array may include a plurality of photon-sensors. The crystal elements may form a plurality of crystal groups along the first direction. The PET detector may further include a plurality of optical separators (e.g., a first optical separator, a second optical separator, a third optical separator) of the same or different lengths configured to control light transmission in the PET detector. The position of the photon gamma interaction in a crystal group may be determined based on output information of photon-sensors optically coupled with the crystal group.

FIG. 1 is a schematic diagram illustrating an exemplary imaging system 100 according to some embodiments of the present disclosure. In some embodiments, the imaging system 100 may be a single-modality system, such as a positron emission tomography (PET) imaging system. Alternatively, the imaging system 100 may be a multi-modality system, such as a PET-CT imaging system, a PET-MRI imaging system, etc.

In some embodiments, the imaging system 100 may include a PET imaging device 110, a network 120, one or more terminals 130, a computing device 140, and a storage device 150. In some embodiments, the components of the imaging system 100 may be connected to each other via the network 120. Alternatively or additionally, the components of the imaging system 100 may be directly connected to each other.

The PET imaging device 110 may scan an object and generate scanning data corresponding to the object. The object may include but is not limited to one or more organs, one or more types of tissues, or the like, of a patient. In some embodiments, the PET imaging device 110 may be a medical scanning device, for example, an SPET device, a PET device, a PET-CT device, a PET-MRI device, etc. The PET imaging device 110 may include a gantry 111, a detector 112, a scanning area 113, and a table 114. An object may be placed on the table 114. The table 114 may deliver the object to a target location in the scanning area 113. The detector 112 may detect radiation rays (e.g., gamma photons) emitted from the object in the scanning area 113. In some embodiments, the detector 112 may include a plurality of detector modules. The detector modules may be arranged in a suitable configuration, including but not limited to a ring (e.g., a detector ring), a rectangle, a triangle, or an array. In some embodiments, the detector 112 may include a plurality of crystal elements, a plurality of photon-sensors, and one or more optical separators as described elsewhere in the present disclosure.

For the convenience of description, a coordinate system including an X axis, a Y axis, and a Z axis is introduced. As shown in FIG. 1, the Z axis direction may refer to a direction along which the object is moved into and out of the scanning area 113. The X axis direction and the Y axis may be perpendicular to each other, and form an x-y plane.

In application, a tracer (e.g., a radioactive isotope) may be injected into an object (via, for example, blood vessels of a patient). The atoms of the tracer may be incorporated into biologically active molecules. The molecules may gather in tissue of the patient. When a sufficient amount of the molecules are estimated to have gathered in the tissue (e.g., in an hour), the patient may be positioned on the table 114. The radioactive isotope may undergo a positron emission decay (i.e., the beta decay) and emits positrons. The positrons may interact with electrons inside the tissue (the interaction between positrons and electrons is called annihilation). The annihilations of the electrons and positrons may each produce a pair of annihilation photons that move in approximately opposite directions. When the annihilation photons strike into a crystal element of the detector 112, the annihilation photons may be absorbed by the crystal element, generating bursts of optical photons (e.g., visible light photons) that, in turn, may be detected by one or more photon-sensors. The interaction between the annihilation photons and the crystal element that produces bursts of optical photons may be referred to as a photon gamma interaction herein. The depth of the photon gamma interaction along an extension direction of the crystal element where the photon gamma interaction occurs may be referred to as a DOI.

An image may be generated by the computing device 140 based on the information associated with the annihilation photons. For example, the computing device 140 may determine the time-of-flight information associated with each of the pairs of annihilation photons. The computing device 140 may also determine DOI information based on output information of the photon-sensors in the detector 112. The computing device 140 may further determine location where the annihilation happens based on the time information and the DOI information. After the locations of annihilations are determined, the computing device 140 may generate a projection image (also referred to as a sonogram) based on the locations of the annihilations. The computing device 140 may reconstruct images based on the projection image and reconstruction techniques such as filtered back projection (FBP). The reconstructed images may indicate the tissue that contains a large number of biologically active molecules of the tracer. In some embodiments, the number of molecules of the tracer in a region may be related to biological functions of the tissues in the region. For example, if fluorodeoxyglucose (FDG) is used as the tracer in a PET scan, the number of tracer molecules in a region may be proportional to the rate of metabolism of glucose in the region. As tumors generally consume a huge amount of glucose, the region with a large number of molecules may be identified in a reconstructed image as tumor tissue.

The network 120 may include any suitable network that can facilitate the exchange of information and/or data between the components of the imaging system 100. In some embodiments, one or more components of the imaging system 100 (e.g., the PET imaging device 110, the terminal 130, the computing device 140, the storage device 150, etc.) may communicate information and/or data with one or more other components of the imaging system 100 via the network 120. For example, the computing device 140 may obtain image data (e.g., time information, energy information, DOI information) from the PET imaging device 110 via the network 120. As another example, the computing device 140 may obtain user instructions from the terminal 130 via the network 120. The network 120 may include a public network (e.g., the Internet), a private network (e.g., a local area network (LAN), a wide area network (WAN)), etc.), a wired network (e.g., an Ethernet network), a wireless network (e.g., an 802.11 network, a Wi-Fi network, etc.), a cellular network (e.g., a Long Term Evolution (LTE) network), a frame relay network, a virtual private network (“VPN”), a satellite network, a telephone network, routers, hubs, switches, server computers, and/or any combination thereof. Merely by way of example, the network 120 may include a cable network, a wireline network, a fiber-optic network, a telecommunications network, an intranet, a wireless local area network (WLAN), a metropolitan area network (MAN), a public telephone switched network (PSTN), a Bluetooth™ network, a ZigBee™ network, a near field communication (NFC) network, or the like, or any combination thereof.

The terminal 130 may include a mobile apparatus 130-1, a tablet computer 130-2, a laptop computer 130-3, or the like, or any combination thereof. In some embodiments, the mobile apparatus 130-1 may include a smart home device, a wearable device, a mobile device, a virtual reality device, an augmented reality device, or the like, or any combination thereof. In some embodiments, the terminal 130 may be part of the computing device 140.

The computing device 140 may process data and/or information obtained from the PET imaging device 110, the terminal(s) 130, and/or the storage device 150. For example, the computing device 140 may process image data (including time information, energy information, DOI information, etc.) and reconstruct an image based on the image data. In some embodiments, the computing device 140 may be a single server or a server group. The server group may be centralized or distributed. In some embodiments, the computing device 140 may be local or remote. For example, the computing device 140 may access information and/or data stored in the PET imaging device 110, the terminal(s) 130, and/or the storage device 150 via the network 120. As another example, the computing device 140 may be directly connected to the PET imaging device 110, the terminal(s) 130 and/or the storage device 150 to access stored information and/or data. In some embodiments, the computing device 140 may be implemented on a cloud platform. Merely by way of example, the cloud platform may include a private cloud, a public cloud, a hybrid cloud, a community cloud, a distributed cloud, an inter-cloud, a multi-cloud, or the like, or any combination thereof. In some embodiments, the computing device 140, or a portion of the computing device 140 may be integrated into the PET imaging device 110.

The computing device 140 may include a processor, a storage module, an input/output (I/O) and a communication port. The processor may execute computer instructions (e.g., program code) and perform functions of the computing device 140 described herein. The computer instructions may include, for example, routines, programs, objects, components, data structures, procedures, modules, and functions, which perform particular functions described herein. The storage module may store data/information obtained from the PET imaging device 110, the terminal 130, the storage device 150, and/or any other component of the imaging system 100. In some embodiments, the storage module may include a mass storage, a removable storage, a volatile read-and-write memory, a read-only memory (ROM), or the like, or any combination thereof. The I/O may input and/or output signals, data, information, etc. In some embodiments, the I/O may enable a user interaction with the computing device 140. In some embodiments, the I/O may include an input device and an output device. Examples of the input device may include a keyboard, a mouse, a touch screen, a microphone, or the like, or any combination thereof. Examples of the output device may include a display device, a loudspeaker, a printer, a projector, or the like, or any combination thereof. The communication port may be connected to a network (e.g., the network 120) to facilitate data communications. The communication port may establish connections between the computing device 140 and the PET imaging device 110, the terminal 130, and/or the storage device 150. The connection may be a wired connection, a wireless connection, any other communication connection that can enable data transmission and/or reception, and/or any combination of these connections.

The storage device 150 may store data, instructions, and/or any other information. In some embodiments, the storage device 150 may store data obtained from the terminal(s) 130 and/or the computing device 140. In some embodiments, the storage device 150 may store data and/or instructions that the computing device 140 may execute or use to perform exemplary methods described in the present disclosure. In some embodiments, the storage device 150 may store image data (e.g., time information, energy information, DOI information) obtained from the PET imaging device 110. In some embodiments, the storage device 150 may include a mass storage, removable storage, a volatile read-and-write memory, a read-only memory (ROM), or the like, or any combination thereof. In some embodiments, the storage device 150 may be connected to the network 120 to communicate with one or more other components of the imaging system 100 (e.g., the computing device 140, the terminal(s) 130, etc.). Alternatively or additionally, the storage device 150 may be part of the computing device 140.

It should be noted that the above description of the imaging system 100 is merely provided for the purposes of illustration, and not intended to limit the scope of the present disclosure. For persons having ordinary skills in the art, multiple variations and modifications may be made under the teachings of the present disclosure. For example, the assembly and/or function of the imaging system 100 may be varied or changed according to specific implementation scenarios. Merely by way of example, some other components may be added into the imaging system 100, such as a patient positioning unit, data acquisition electronics, power supplies, and other devices or units. However, those variations and modifications do not depart from the scope of the present disclosure.

FIG. 4 is a schematic diagram illustrating an exemplary detector 400 according to some embodiments of the present disclosure. In some embodiments, the detector 400 may be an example of the detector 112 or a portion of the detector 112. The detector 400 may be configured to detect annihilation photons generated by annihilation events during a scan of an object.

As shown in FIG. 4, the detector 400 may include a crystal array 410, a photon-sensor array 420 optically coupled with the crystal array 410, one or more first optical separators 412, and one or more second optical separators 413. The crystal array 410 may include a plurality of crystal elements 411 (e.g., crystal elements 411 a, 411 b, 411 c, and 411 d) configured to receive annihilation photons from the object. For simplicity and illustration purposes, the crystal array 410 as illustrated includes only a row of crystal elements 411. It is not intended to be limiting. In some embodiments, the crystal array 410 may include a two-dimensional array of crystal elements. See, e.g., FIGS. 11a, 11b , and 13 and the description thereof. The photon-sensor array 420 may include a plurality of photon-sensors 421 configured to detect optical photons emitted from the first ends of the crystal elements 411.

The crystal elements 411 of the crystal array 410 may be arranged along a first direction, forming a crystal column as shown in FIG. 4. Each crystal element 411 may include a first end S1 and a second end S2 and extend along a third direction from the first end S1 to the second end S2. As used herein, the first end S1 of a crystal element 411 may refer to an end through which an optical photon exits the crystal element 411 to enter a photon-sensor 421. The second end S2 of a crystal element 411 may refer to an end through which radiation rays (e.g., gamma rays caused by annihilation events) enter the crystal element 411. The second end S2 of a crystal element 411 may be closer to the scanned object than the first end S1 of the same crystal element 411.

A crystal element 411 may be made of any material that can absorb radiation rays and emit a fraction of the absorbed radiation rays as light. For example, the crystal element 411 may be made of, for example, bismuth germanium oxide (BGO), lutetium oxyorthosilicate (LSO), lutetium-yttrium oxyorthosilicate (LYSO), lutetium-gadolinium oxyorthosilicate (LGSO), gadolinium oxyorthosilicate (GSO), yttrium oxyorthosilicate (YSO), barium fluoride, sodium iodide, cesium iodide, lead tungstate, yttrium aluminate, yttrium aluminate, lanthanum chloride, lutetium aluminum perovskite, lutetium disilicate, lutetium aluminate, lutetium iodide, thallium bromide, or the like, or any combination thereof. Different crystal elements 411 may be made of the same material or different materials.

The sizes and/or the shapes of different crystal elements 411 may be the same or different. For example, the crystal elements 411 of the crystal array 410 may have a uniform size and shape. As another example, different crystal elements 411 may have different lengths. As used herein, the length of a crystal element 411 may refer to its length along its extension direction, i.e., the third direction. In some embodiments, the size and/or the shape of a crystal element 411 may vary according to one or more conditions including, for example, an image resolution of the detector 400, a size of the detector 400, or the like, or any combination thereof.

In some embodiments, each of the plurality of photon-sensors 421 may be optically single-end-coupled with one or more crystal elements 411 of the crystal array 410. Different photon-sensors 421 may be coupled with the same number (or count) of or different numbers (or counts) of crystal elements 411. A photon-sensor 421 may be coupled to the corresponding crystal element(s) 411 in any suitable manner. For example, a photon-sensor 421 may contact the corresponding crystal element(s) 411 directly. As another example, a photon-sensor 421 may be fixed to the corresponding crystal element(s) 411 through one or more adhesive materials, e.g., a light transmitting glue. As still another example, a photon-sensor 421 may be single-end-coupled with the corresponding crystal element(s) 411 via a light transmitting material, e.g., a piece of glass. In some embodiments, one or more photon-sensors 421 may be optically coupled with a crystal element 411, e.g., any one of 411 a-411 d, to receive photons from a single end (e.g., the first end S1) of the crystal element 411. As used herein, a detector that uses one or more photon-sensors 421 to detect photons from a single end of each of the crystal elements 411 may be referred to as a detector having a single-end read-out structure.

In some embodiments, a photon-sensor 421 may include a phototube, a photomultiplier Tube (PMT), a photodiode, an active-pixel sensor, a bolometer, a gaseous ionization detector, a photoresistor, a phototransistor, an avalanche photodiode (APD), a single-photon avalanche photodiode (SPAD), a silicon photomultiplier (SiPM), a digital silicon photomultiplier (DSiPM), or the like, or any combination thereof. Different photon-sensors 421 may be of the same type or different types of photon-sensors.

In some embodiments, the crystal elements 411 of the crystal array 410 may form a plurality of crystal groups 430 along the first direction. Each crystal group 430 may include at least two crystal elements of the plurality of crystal elements 411. For example, as illustrated in FIG. 4, the crystal elements 411 a and 411 b may form a crystal group 430 a, and the crystal elements 411 c and 411 d may form a crystal group 430 b. It should be noted that the examples shown in FIG. 4 are merely provided for the purposes of illustration, and not intended to limit the scope of the present disclosure. A crystal group 430 may include any number or count of crystal elements 411. For example, the crystal elements 411 a, 411 b, 411 c, and 411 d may together form a crystal group 430.

In some embodiments, light sharing between two adjacent (or neighboring) crystal elements 411 belonging to one crystal group 430 may be allowed, while light sharing between two adjacent crystal groups may be restricted or substantially restricted, in order to facilitate the position determination of a photon gamma interaction. As used herein, two crystal elements 411 may be regarded as being adjacent to each other or neighboring if there is no other crystal element located between them. In some embodiments, two adjacent or neighboring crystal elements may be spaced apart by a void space, an item other than a crystal element (e.g., a film, a coating, a layer of a material different from the material of any crystal element of the neighboring crystal elements, etc.), or the like, or a combination thereof. Merely by way of example, a space may exist between two neighboring crystal elements, and a portion of the space may be filled with an optical separator (e.g., a second optical separator described elsewhere in the present disclosure) and a portion of the space may be void.

Two crystal groups may be regarded as being adjacent to or neighboring each other if there is no other crystal group located between them. In some embodiments, two adjacent or neighboring crystal groups may be spaced apart by a void space, an item other than a crystal element of a crystal group (e.g., a film, a coating, a layer of a material different from the material of any crystal element of the crystal elements of the neighboring crystal groups, etc.), or the like, or a combination thereof. Merely by way of example, a space may exist between two neighboring crystal groups, and a portion of the space may be filled with an optical separator (e.g., a first optical separator described elsewhere in the present disclosure) and a portion of the space may be void. As another example, a space between two neighboring crystal groups may be substantially completely filled with an optical separator (e.g., a first optical separator described elsewhere in the present disclosure).

To control the light transmission between two adjacent crystal elements 411 or crystal groups 430, a plurality of optical separators may be used in the detector 400. An optical separator may include a reflective film, a reflective foil, a reflective coating (e.g., a white reflective coating), or any other material that can prevent or substantially prevent light transmission. For example, as illustrated in FIG. 4, a first optical separator 412 of a first length may be configured between two adjacent crystal groups 430 a and 430 b. A second optical separator 413 of a second length may be configured between two adjacent crystal elements 411 a and 411 b of the crystal group 430 a. The first length of the first optical separator 412 may be greater than the second length of the second optical separator 413, so that more space is available for optical photons to travel between the crystal groups 430 a and 430 b than between the crystal elements 411 a and 411 b. As used herein, a length of an optical separator may refer to its length along the extension direction of a crystal element 411, i.e., the third direction.

In some embodiments, the first optical separator 412 may extend along the third direction from the first end S1 of at least one of the two crystal elements 411 between which it is located, e.g., the crystal elements 411 b and 411 c. The length of the first optical separator 412 may be equal to or substantially equal to that of at least one of the crystal elements 411 b and 411 c, so as to completely or substantially completely block the light transmission between the crystal groups 430 a and 430 b.

In some embodiments, the second optical separator 413 may extend along the third direction from the first end S1 of at least one of the two crystal elements 411 between which it is located, e.g., the crystal elements 411 a and 411 b. The length of the second optical separator 413 may be less than that of at least one of the crystal elements 411 a and 411 b, so as to partially block the light transmission between the crystal elements 411 a and 411 b. In some embodiments, the length of the second optical separator 413 may be equal to or greater than a half of the length of at least one of the crystal elements 411 a and 411 b.

For illustration purposes, only one first optical separator 412 and one second optical separator 413 are illustrated in FIG. 4, but the detector 400 may include any number or count of first optical separators 412 and second optical separators 413. For example, the detector 400 may include a plurality of first optical separators 412 and/or a plurality of second optical separators 413. Each first optical separator 412 may be located between two adjacent or neighboring crystal groups 430, and extend along the third direction from the first end S1 of at least one of two adjacent crystal elements between which it is located. The length of each first optical separator 412 may be equal to a length of at least one of the two adjacent crystal elements between which it is located. Each second optical separator 413 may be located between two adjacent or neighboring crystal elements 411 of a crystal group 430, and extend along the third direction from the first end S1 of at least one of two adjacent or neighboring crystal elements between which it is located. The length of each second optical separator 413 may be less than a length of at least one of the two adjacent or neighboring crystal elements between which it is located. The lengths of different first optical separators 412 in the detector 400 may be the same or different. The lengths of different second optical separators 413 in the detector 400 may be the same or different. In some embodiments, the detector 400 may include a first optical separator 412 located between each pair of adjacent or neighboring crystal groups 430. Additionally or alternatively, the detector 400 may include a second optical separator 413 located between each pair of adjacent or neighboring crystal elements 411 of each crystal group 430.

It should be noted that the example illustrated in FIG. 4 is merely provided for the purposes of illustration, and not intended to limit the scope of the present disclosure. For persons having ordinary skills in the art, multiple variations and modifications may be made under the teachings of the present disclosure. However, those variations and modifications do not depart from the scope of the present disclosure. In some embodiments, the crystal array 410 may include any suitable number or count of the crystal elements 411. For example, the crystal array 410 may include an even number or count (e.g., two, four, six, eight, or twelve) of the crystal elements 411. The crystal elements 411 may be arranged in any suitable manner. For example, the crystal elements 411 of the crystal array 410 may be arranged in a two-dimensional array including a plurality of rows and columns. In some embodiments, the first length of a first optical separator 412 may be equal to the second length of a second optical separator 413

FIG. 5 is a schematic diagram illustrating a perspective view of an exemplary crystal group 430 a according to some embodiments of the present disclosure. As described in connection with FIG. 4, the crystal group 430 a may include the crystal element 411 a and the crystal element 411 b. The photon-sensor 421 a and the photon-sensor 421 b (shown as darkened areas in FIG. 5) may be optically coupled with the crystal element 411 a and the crystal element 411 b, respectively.

The shaded areas illustrated in FIG. 5 represent one or more optical separators configured to block or partially block the light transmission between the crystal elements 411. For example, the first optical separator 412 may substantially or completely cover a side surface of the crystal element 411 b to prevent the optical photons in the crystal group 430 a from travelling through the side surface facing an adjacent crystal group to the adjacent crystal group (not shown in FIG. 5). The first length of the first optical separator 412 may be equal to the length of the crystal element 411 b. The second optical separator 413 may be located between the crystal elements 411 a and 411 b. The second optical separator 413 may extend along the third direction from the first end S1 of crystal element 411 a or 411 b. The second length of the second optical separator 413 may be less than the length of the crystal element 411 a or 411 b so that it may partially block the optical photon transmission between the crystal elements 411 a and 411 b.

In some embodiments, the length of the second optical separator 413 may be equal to N % of the length of the crystal element 411 a or 411 b. N may have any suitable positive value. In some embodiments, N may be in the range of 30 to 90, 50 to 85, etc. For example, N may be 30, 40, 50, 60, 70, 80, 85, or 90. N may be a parameter used in the position determination of a photon gamma interaction in the detector 400. In some embodiments, N may be a default parameter stored in a storage device (e.g., the storage device 150). Additionally or alternatively, N may be set manually or be determined by one or more components of the imaging system 100 according to different situations.

FIGS. 6a and 6b are schematic diagrams illustrating exemplary photon gamma interactions occurred in an exemplary crystal group 430 a according to some embodiments of the present disclosure.

A photon gamma interaction occurred in the crystal group 430 a may excite one or more optical photons that may be detected by the corresponding photon-sensors 421 a and/or 421 b as described elsewhere in this disclosure. The number or count of optical photons detected by the photon-sensor 421 a or 421 b may be associated with a position of the photon gamma interaction in the crystal group 430 a. For example, as illustrated in FIG. 6a , a photon gamma interaction 4 occurs at a position closer to the first end S1 (or lower) than the top of the second optical separator 413 (denoted as T in FIG. 6a ). The optical photon(s) produced by the photon gamma interaction 4 may be blocked or substantially blocked by the second optical separator 413 from travelling into the crystal element 411 b. Accordingly, all or almost all the optical photons excited by the photon gamma interaction 4 may be detected by the photon-sensor 421 a. Merely by way of example, as shown in FIG. 6a , the photon gamma interaction 4 may generate three optical photons 4 a, 4 b, and 4 c. The optical photons 4 a and 4 b are detected by the photon-sensor 421 a directly, and the optical photon 4 c is reflected by the second optical separator 413 and then detected by the photon-sensor 421 a.

As another example, as illustrated in FIG. 6b , a photon gamma interaction 5 occurs at a position farther to the first end S1 (or higher) than the top of the second optical separator 413 (denoted as T in FIG. 6b ). The optical photon(s) excited by the photon gamma interaction 5 may be partially blocked by the second optical separator 413 from travelling into the crystal element 411 b. Accordingly, the optical photons may be detected by both the photon-sensor 421 a and the photon-sensor 421 b. Merely by way of example, the photon gamma interaction 5 may generate three optical photons 5 a, 5 b, and 5 c. The optical photons 5 a and 5 b are detected by the photon-sensor 421 a directly, and the optical photon 5 c travels into the crystal element 411 b and is detected by the photon-sensor 421 b.

FIG. 7 is a schematic diagram illustrating an exemplary crystal group 700 according to some embodiments of the present disclosure.

The crystal group 700 may be similar to the crystal group 430 a as described in connection with FIGS. 4 to 6, except that the second ends S2 of the crystal elements 411 a and 411 b may be integrated into a single end. In some embodiments, the crystal group 700 may be manufactured by partially cutting a single crystal block into the crystal elements 411 a and 411 b. The cut may be extended from the first end S1 of the crystal block toward its second end S2, and the cut may extend to a depth without reaching the second end S2. The second optical separator 413 may be made by filling the cutting grooves of the crystal block with one or more light reflecting materials. In such a case, the light transmission between the crystal elements 421 a and 421 b may be allowed in the uncut portion near the second end S2 while be prevented in the cut portion near the first end S1. The first optical separator(s) 412 may be formed by coating a side surface of the crystal elements 411 a and/or 411 b with a light reflecting material. In such a case, the light transmission between the crystal group 700 and an adjacent group (not shown in FIG. 7) may be prevented.

In some embodiments, the position of a photon gamma interaction 7 in the crystal group 700 may be determined based on the output information of the photon-sensors 421 a and 421 b. The output information may reflect the energy of the optical photons excited by the photon gamma interaction 6 and detected by the photon-sensors 421 a and/or 421 b. In some embodiments, the crystal element in which the photon gamma interaction 6 occurs (also referred to as a target crystal element), and/or the depth of the photon gamma interaction 6 in the target crystal element may be determined based on the output information. More descriptions regarding the determination of a position of a photon gamma interaction may be found elsewhere in the present disclosure. See, e.g., FIGS. 16 and 17 and relevant descriptions thereof.

FIG. 8a is a schematic diagram illustrating an exemplary detector 800 a according to some embodiments of the present disclosure. In some embodiments, the detector 800 a may be an example of the detector 112 or a portion of the detector 112. The detector 800 a may be similar to the detector 400, except for certain components or features.

As illustrated in FIG. 8a , the detector 800 a may include a plurality of crystal groups 700 (e.g., a crystal group 700 a and a crystal group 700 b) arranged along the first direction. The second ends S2 of the crystal elements 411 in each crystal group 700 may be integrated into a single end. For example, the second ends S2 of the crystal elements 411 a and 411 b of the crystal group 700 a may form an integrated end.

In some embodiments, the detector 800 a may be made by cutting a single crystal block along the third direction to generate a plurality of cuts. The cuts may extend from the first end S1 of the crystal block and have various lengths along the third direction. For example, to form the plurality of crystal groups 700, one or more first cuts may be made to penetrate the crystal block from its first end S1 to its second end S2. The cutting grooves of the first cuts may be filled at least partially with one or more light reflecting materials, and the light reflecting material(s) in each cutting groove may form a first optical separator 412. As another example, to form the crystal elements in each crystal group 700, one or more second cuts may be made from the first end S1 toward but not reaching the second end S2. The cutting grooves of the second cuts may be filled at least partially with one or more light reflecting materials, and the light reflecting material(s) in each cutting groove may form a second optical separator 413.

In some embodiments, the detector 800 a may be manufactured by assembling a plurality of crystal groups 700 along the first direction. Each crystal group 700 may be manufactured in a similar manner as described in FIG. 7. The crystal groups 700 may be assembled together in any suitable manner, for example, by one or more adhesive materials.

FIG. 8b is a schematic diagram illustrating a perspective view of an exemplary crystal group 800 b according to some embodiments of the present disclosure. The crystal group 800 b may be similar to the crystal group 430 (e.g., the crystal group 430 a) as described elsewhere in this disclosure (e.g., FIGS. 4 and 5 and relevant descriptions), except for certain components or features.

The crystal group 800 b may include the crystal elements 411 a, 411 b, 411 c, and 411 d. The photon-sensors 421 a, 421 b, 421 c, and 421 d may be optically coupled with the crystal elements 411 a, 411 b, 411 c, and 411 d, respectively. A first optical separator 412 may substantially or completely cover a side surface of the crystal group 800 b to prevent optical photons from travelling through the side surface facing an adjacent crystal group to the adjacent crystal group (not shown in FIG. 8b ). A second optical separator 413 (e.g., 413 a, 413 b, and 413 c) may be positioned between each pair of adjacent crystal elements in the crystal group 800 b. The length of each second optical separator 413 in the second optical separator group 440 may be smaller than the length of the first optical separator 412. The lengths of different second optical separators 413 may be the same or different. In some embodiments, the second optical separators 413 a, 413 b, and 413 c may form a second optical separator group 440.

It should be noted that the examples illustrated in FIGS. 7 to 9 are merely provided for the purposes of illustration, and not intended to limit the scope of the present disclosure. A crystal group (e.g., the crystal group 700 or 800 b) may include any number or count of crystal elements 411. The second ends S2 of crystal elements 411 in a crystal group may be separate or integrated into a single end.

FIGS. 9a and 9b are schematic diagrams illustrating exemplary photon gamma interactions occurred in an exemplary crystal group 900 according to some embodiments of the present disclosure. The crystal group 900 may be similar to the crystal group 430 a as described in connection with FIGS. 4 to 6 except for certain features including those described below.

As shown in FIGS. 9a and 9b , the crystal group 900 may include a crystal element 411 a, a crystal element 411 b, and an optical window (not shown in figures). The optical window may allow light transmission between the two crystal elements 411 a and 411 b of the crystal group 900 so that a photon excited by an photon gamma interaction in a first crystal element of the crystal group 900 can travel into a second crystal element of the crystal group 900 through the second end of the first crystal element, the optical window, and the second end of the second crystal element. For example, a photon excited by a photon gamma interaction in the crystal element 411 a may travel into the crystal element 411 b through the second end S2 of the crystal element 411 a, the optical window, and the second end S2 of the crystal element 411 b.

In some embodiments, the optical window may include a plurality of optical separators and a light transmission medium 902. For each of crystal elements of the crystal group 900, an optical separator may be mounted on each side surface of the crystal element facing a neighboring crystal element of the crystal element along the first direction. The optical separator may be similar to the first optical separator 412 as described elsewhere in this disclosure. See, e.g., FIGS. 4 to 8 b and the relevant descriptions. The length of the optical separator may be equal to or substantially equal to a length of at least one of the crystal element or the neighboring crystal element. For example, as illustrated in FIGS. 9a and 9b , an optical separator 901 a may be mounted on a right side surface of the crystal element 411 b facing a neighboring crystal element in a neighboring crystal group (not shown in figures) along the first direction. The length of the optical separators 901 a may be equal to the crystal element 411 b to prevent a photon in the crystal element 411 b from travelling through the right side surface of the crystal element 411 to a neighboring crystal element (not shown in figures). An optical separator 901 b may be mounted between a right side surface of the crystal element 411 a and a left side surface of the crystal element 411 b along the first direction as illustrated in FIGS. 9a and 9b . The length of the optical separators 901 b may be equal to the crystal element 411 b and/or the crystal element 411 a to prevent a light transmission between the crystal elements 411 a and 411 b through their side surfaces facing each other.

In some embodiments, two neighboring crystal elements of the crystal group 900 may share an optical separator (e.g., a reflective film) located between the two neighboring crystal elements. Alternatively, each of the two neighboring crystal elements may be coated with an optical separator on its side surface facing the other crystal element of the crystal group 900. For example, both the right side surface of the crystal element 411 a and the left side surface of the crystal element 411 b may be coated with a reflective coating.

The light transmission medium 902 may cover the second ends S2 of the crystal elements 411 a and 411 b. Each side surface of the light transmission medium 902 that faces the light transmission medium 902 of a neighboring crystal group of the crystal group 900, e.g., side surfaces 902 a and 902 b may be coated with a light reflective material so as to completely or substantially completely prevent a photon in the crystal group 900 from traveling out of the light transmission medium 902 from the side surfaces of the light transmission medium 902. The light transmission medium 902 may be made of any material substance (e.g., glass) that allows light to pass through. Photons excited by a photon gamma interaction occurred in one crystal element of the crystal group 900 may travel into the light transmission medium 902, be reflected by one of the side surfaces of the light transmission medium 902 for one or more times, and then travel into another crystal element of the crystal group 900. For example, as illustrated in FIG. 9b , a photon 10B generated by photon gamma interaction 10 in the crystal element 411 a may travel into the crystal element 411 b through the light transmission medium 902.

The position of a photon gamma interaction occurred in the crystal group 900 may be determined based on the output information of the photon-sensors 421 a and 421 b optically coupled with the crystal group 900. In some embodiments, the position of a photon gamma interaction may be determined based on the energy detected by the photon-sensors 421 a and 421 b. For example, as illustrated in FIG. 9a , a photon gamma interaction 9 occurs at a position closer to the first end S1 than the second end of the crystal element 411 a. All or most all the photons (e.g., photon 9A, 9B, and 9C) produced by the photon gamma interaction 9 may be detected by the photon-sensor 421 b optically coupled with the crystal element 411 a. As another example, as illustrated in FIG. 9b , the photon gamma interaction 10 occurs at a position closer to the second end S2 than the first end S1 of the crystal element 411 a. A portion of the photons generated by the photon gamma interaction 10 (e.g., photons 10A and 10B) may be detected by the photon-sensor 421 a. A portion of the photons (e.g., the photon 10B) may travel into the crystal element 411 b via the light transmission medium 902, and be detected by the photon-sensor 421 b. In some embodiments, the photon gamma interaction position may be determined by performing process 1600 as described in connection with FIG. 16.

Additionally or alternatively, the position of a photon gamma interaction in the crystal group 900 may be determined based on the time when the photons generated by the photon gamma interaction are received the photon-sensors 421 a and 421 b. Taking the photon gamma interaction 10 as an example, a time difference between a first time point when the photon-sensor 421 a receives a photon (e.g., the photon 10A) and a second time point when the photon-sensor 421 b receives a photon (e.g., the photon 10B) may be determined. The DOI of the photon gamma interaction 10 may be estimated based on the time difference and the speed of light. A shorter time difference may indicate that the photon gamma interaction 10 is occurred at a position closer to the second end of the crystal element 411 a.

It should be noted that the crystal group 900 shown in FIGS. 9a and 9b are merely provided for the purposes of illustration, and not intended to limit the scope of the present disclosure. For persons having ordinary skills in the art, multiple variations and modifications may be made under the teachings of the present disclosure. However, those variations and modifications do not depart from the scope of the present disclosure. In some embodiments, the light transmission medium 902 may have any shape and size. In some embodiments, the crystal group 900 may include any number or count of crystal elements.

FIGS. 10a and 10b are schematic diagrams respectively illustrating top views of an exemplary detector 1000 a and an exemplary detector 1000 b according to some embodiments of the present disclosure.

The detectors 1000 a may include a crystal array and a photon-sensor array (shown as darkened areas in FIG. 10a ) optically coupled with the crystal array. The crystal array may include a plurality of crystal elements arranged along a first direction and a second direction. Along the first direction, the crystal elements may form a plurality of columns of crystal elements and define one or more crystal groups. Along the second direction, the crystal elements may form a plurality of rows. In some embodiments, the second direction may be orthogonal to or approximately orthogonal to the first direction. In some embodiments, the first direction may be along the Z-axis, and the second direction may be along the X-axis of a PET imaging device 110 as illustrated in FIG. 1.

As illustrated in FIG. 10a , the detector 1000 a may include two crystal element rows (i.e., a first crystal row g1 and a second crystal row g2) and two crystal columns. The first crystal row g1 may include two crystal elements 1010 a and 1010 b arranged side by side along the second direction, and the second crystal row g2 may include two crystal elements 1010 c and 1010 d arranged side by side along the second direction.

The photon-sensor array may include a plurality of photon-sensors configured to receive optical photons emitted from the crystal elements of the detector 1000 a. Each photon-sensor may be optically coupled with one or more crystal elements. For example, as illustrated in FIG. 10a , the photon-sensor array may include a photon-sensor 1020 a and a photon-sensor 1020 b. The photon-sensor 1020 a may directly or indirectly contact an end of the crystal element 1010 a, optically coupled with at least one of the crystal elements 1010 a and 1010 b (e.g., optically coupled with the crystal element 1010 a) and configured to receive optical photons emitted from the crystal elements 1010 a and 1010 b. The photon-sensor 1020 b may directly or indirectly contact an end of the crystal element 1010 c, optically coupled with the crystal element 1010 c and configured to receive optical photons emitted from the crystal elements 1010 c and 1010 d.

The detector 1000 b may be similar to the 1000 a, except for certain components or features. The detector 1000 b may include a first crystal row g′1 and a second crystal row g′2, each of which may include four crystal elements. The photon-sensor array may include photon-sensors 1020′a, 1020′b, 1020′c, and 1020′d. Each photon-sensor may be optically coupled with two crystal elements that belong to one crystal row. For example, the photon-sensor 1020′a may be coupled with crystal elements 1010′a and 1010′b in the first crystal row g′1 and configured to detect optical photons emitted from them. In some embodiments, the photon-sensor 1020′a and the photon-sensor 1020′b may be aligned with the photon-sensor 1020′c and the photon-sensor 1020′d along the first direction, respectively.

In some embodiments, the crystal elements in a crystal column may form one or more crystal groups (not shown in FIGS. 10a and 10b ) along the first direction. Each crystal group may include at least two crystal elements. One or more optical separators, arranged between crystal elements and/or crystal groups, may be used in the detector 1000 a and/or the detector 1000 b to control light transmission. More descriptions of the optical separators (e.g., a first, a second, and a third optical separator) may be found elsewhere in the present disclosure (e.g., FIG. 11 and the descriptions thereof).

It should be noted that the detectors 1000 a and 1000 b shown in FIGS. 10a and 10b are merely provided for the purposes of illustration, and not intended to limit the scope of the present disclosure. For persons having ordinary skills in the art, multiple variations and modifications may be made under the teachings of the present disclosure. However, those variations and modifications do not depart from the scope of the present disclosure. In some embodiments, the detector 1000 a and/or 1000 b may include any number or count of rows and columns of crystal elements. A photon-sensor may be optically coupled with any number or count of crystal elements. For example, the photon-sensor 1020 a may be optically coupled with the crystal elements 1010 a, 1010 b, 1010 c, and 1010 d, and configured to detect optical photons emitted from the crystal elements 1010 a, 1010 b, 1010 c, and 1010 d. Different photon-sensors may be optically coupled with the same number or count of or different numbers or counts of crystal elements.

FIG. 11a is a schematic diagram illustrating an exemplary detector 1100 a according to some embodiments of the present disclosure. In some embodiments, the detector 1100 a may be an example of the detector 112 or a part of the detector 112.

The detector 1100 a may include a crystal array 1110 and a photon-sensor array 1120 optically coupled with the crystal array 1110. The crystal array 1110 may be similar to the crystal array 410 as described in connection with FIG. 4, except for certain components or features. The crystal elements 411 of the crystal array 1110 may form a plurality of crystal rows arranged in the second direction and a plurality of crystal columns arranged in the first direction. For example, as shown in FIG. 11a , the crystal array 1110 may have a configuration of 9×8 crystal elements. In some embodiments, the second direction may be orthogonal or approximately orthogonal to the first direction. In some embodiments, both of the first direction and the second direction may be orthogonal or approximately orthogonal to an extension direction of the crystal elements of the crystal array 1110 (i.e., the third direction). In some embodiments, the first direction, the second direction, and the third direction may be along the Z-axis, the X-axis, and the Y-axis, respectively, of a PET imaging device 110 as illustrated in FIG. 1.

The photon-sensor array 1120 may include a plurality of photon-sensors 421 arranged along the first direction and the second direction. Each photon-sensor 421 may be optically coupled with one or more of the crystal elements of the crystal array 1110. For example, along the first direction, each photon-sensor 421 may be optically coupled with one crystal element 411 of a crystal column. Along the second direction, each photon-sensor 421 may be optically coupled with one or more crystal elements 411 of a crystal row. In some embodiments, a photon-sensor 421 may completely cover the first ends S1 of two adjacent crystal elements 411, and configured to receive optical photons emitted from the two adjacent crystal elements 411. Alternatively, a photon-sensor 421 may completely cover a first end of a crystal element 411, and configured to detect optical photons emitted from the crystal element 411 and an adjacent or neighboring crystal element of the crystal element 411. A photon-sensor 421 may be optically coupled with the corresponding crystal element(s) 411 in any suitable manner as described elsewhere in the present disclosure (e.g., FIG. 4 and the descriptions thereof).

In some embodiments, in each crystal column, the corresponding crystal elements 411 may form a plurality of crystal groups 1130 along the first direction. The crystal groups 1130 may be similar to the crystal group 700 in FIG. 7. The light transmission between and within the crystal groups 1130 may be controlled by applying one or more first optical separators 412 and one or more second optical separators 413. The arrangement of the first optical separator(s) 412 and second optical separator(s) 413 in and within a crystal group 1130 may be similar to that of the crystal group 700, and the descriptions thereof are not repeated.

Additionally or alternatively, in a crystal row, the light transmission between two adjacent crystal elements 411 along the second direction may be controlled by applying a plurality of third optical separators 1140. For example, as illustrated in FIG. 11a , each third optical separator 1140 may be located between two adjacent crystal elements 411 along the second direction. Each third optical separator 1140 may extend along the third direction from the second end S2 of at least one of the two crystal elements 411 between which it is located. The length of each third optical separator 1140 may be equal to or less than a length of at least one of the crystal elements between which it is located. The lengths of different third optical separators 1140 may be the same or different. In some embodiments, the length of a third optical separator 1140 may be equal to the length of at least one of the crystal elements between which it is located.

In some embodiments, the third optical separators 1140 may be of the same length when a ratio of the number of the crystal elements 411 to the number of the photon-sensors 421 in the detector 1100 a is lower than a threshold (such as 2, 3, 5, 10). In some embodiments, a third optical separator 1140 may be of a greater length if it is located closer to the edge of the crystal array 1110. In some embodiments, a plurality of third optical separators 1140 in a crystal row may form a third optical separator group. In some embodiments, the plurality of third optical separators 1140 may be periodically arranged in the third optical separator group. Descriptions regarding the arrangement of the third optical separators may be found in, for example, CN Application No. 201410231483.6 filed on May 28, 2014, which is hereby incorporated by reference.

FIG. 11b is a schematic diagram illustrating an exemplary detector 1100 b according to some embodiments of the present disclosure. The detector 1100 b may be similar to the detector 1100 a, except for certain components or features. For example, each crystal group in each crystal column of the detector 1100 b may include four crystal elements 411.

It should be noted that the detectors 1100 a and 1100 b are merely provided for the purposes of illustration, and not intended to limit the scope of the present disclosure. For persons having ordinary skills in the art, multiple variations and modifications may be made under the teachings of the present disclosure. However, those variations and modifications do not depart from the scope of the present disclosure. In some embodiments, the crystal array 1110 may include any number or count of crystal rows and any number or count of crystal columns. The number or count of the crystal rows and the number or count of the crystal columns may be the same or different. In some embodiments, the second ends S2 of the crystal elements 411 of a crystal group 1130 may be integrated into a single end. In some embodiments, a third optical separator 1140 may be replaced by an external light guide (e.g., a piece of glass) when the ratio of the number or count of the crystal elements 411 to the number or count of the photon-sensors 421 in the detector 1100 a or 1100 b is lower than a threshold (such as 2, 3, 5, 10).

FIG. 12a is a schematic diagram illustrating an exemplary inter-crystal penetration phenomenon according to some embodiments of the present disclosure. FIG. 12b is a schematic diagram illustrating an exemplary inter-crystal scatter (ICS) phenomenon according to some embodiments of the present disclosure.

When an annihilation photon travels through crystal elements of a PET device, it may undergo an ICS and/or an inter-crystal penetration phenomenon, which may result in a reduction in the resolution of the PET device. As shown in FIG. 12a , the inter-crystal penetration phenomenon occurs when an annihilation photon passes through a crystal element 1210 without interacting with the crystal element 1210, interacts with another crystal element 1220, and a corresponding optical photon is detected by a photon-sensor corresponding to the crystal element 1220. In some embodiments, the inter-crystal penetration may be more likely to occur to an annihilation photon that enters a crystal element from an angle (with the vertical direction along the length of the crystal element in the extension direction), for an annihilation photon of a higher energy, and/or when the attenuation coefficient of the detector material decreases.

As shown in FIG. 12b , an ICS occurs when an annihilation photon enters a crystal element 1230, undergoes one or more Compton scatters, interacts with one or more crystal elements other than the crystal element 1230, and a corresponding optical photon is detected by one or more photon-sensors corresponding the crystal element(s) other than the crystal element 1230, such as a crystal element 1240. In some embodiments, ICS may be likely to occur to annihilation photons that enter the crystal elements vertically (e.g., along the length of the crystal element 1230 in its extension direction) or non-vertically.

Both the ICS phenomenon and inter-crystal penetration phenomenon may cause an inaccurate DOI determination and LOR assignment because an annihilation photon may excite an optical photon that is detected by a photon-sensor optically coupled with a crystal element other than the one from which the annihilation photon initially enters. As such, the ICS phenomenon and/or inter-crystal penetration phenomenon may need to be considered in the DOI determination.

FIG. 13 is a schematic diagram illustrating an exemplary ICS phenomenon in an exemplary crystal array 1300 according to some embodiments of the present disclosure. As illustrated, the crystal array 1300 may include a plurality of crystal elements A1, A2, A3, B1, B2, and B3. The crystal elements A1 and B1 may form a crystal group A1/B1, the crystal elements A2 and B2 may form a crystal group A2/B2, and the crystal elements A3 and B3 may form a crystal group A3/B3. A plurality of photon-sensors (not shown in FIG. 13) may be optically coupled with one or more of the crystal elements of the crystal array 1300 to detect optical photons emitted from the corresponding crystal element(s). For illustration purposes, the photon-sensors optically coupled with the crystal elements in one crystal group may be referred to as a photon-sensor group.

In some embodiments, an annihilation photon may undergo an ICS when travelling in a crystal element from which it initially enters. For example, as shown in FIG. 13, an annihilation photon may be scattered after entering the crystal element A1, and the optical photon(s) produced by the annihilation photon may be detected in one or more of the crystal groups A1/B1, A2/B2, and A3/B3. In some embodiments, the annihilation photon may interact with the crystal element A1 (shown as a photon gamma interaction 7 in FIG. 13). The position of the photon gamma interaction 7 may be determined based on the respective energy detected in the crystal groups A1/B1, A2/B2, and A3/B3. Without considering the ICS, the position of the photon gamma interaction 7 may be determined inaccurately. For example, a position 1320 may be determined as the position of the photon gamma interaction 7 if the ICS is neglected.

Methods for determining the position of a photon gamma interaction (e.g., the photon gamma interaction 7) provided herein may take the ICS phenomenon into consideration. For example, in each crystal group, a candidate position may be determined based on the energy detected by the corresponding photon-sensor group. Each candidate position in a crystal group may include a candidate depth of the photon gamma interaction within the crystal group. Then the position of the photon gamma interaction may be determined based on the candidate positions. In some embodiments, the candidate position with the smallest candidate depth may be selected as the position of the photon gamma interaction. For example, as illustrated in FIG. 13, a candidate position 1310 with a candidate depth d1, a candidate position 1320 with a candidate depth d2, and a candidate position 1330 with a candidate depth d3 may be determined in the crystal groups A1/B1, A2/B2, and A3/B3, respectively. The candidate position 1310 has the smallest candidate depth, showing that it is the initial position of the photon gamma interaction 7 and therefore is deemed as the position of the photon gamma interaction 7. More descriptions regarding the determination of a photon gamma interaction may be found elsewhere in the present disclosure. See, e.g., FIGS. 16 and 17 and relevant descriptions thereof.

FIG. 14a is a schematic diagram illustrating an exemplary detector 1400 according to some embodiments of the present disclosure. FIG. 14b illustrates a perspective view of a part of the detector 1400 according to some embodiments of the present disclosure.

As illustrated, the detector 1400 may include a plurality of detector rings 1401 (e.g., detector rings 1401-1 to 1401-n) arranged along an axial direction (also referred to as the Z axis direction) of the detector 1400. The detector rings 1401 may form a scanning channel configured to accommodate an object to be examined. The detector ring 1401 may have any suitable configuration. For example, each detector ring 1401 may form a complete circle as shown in FIG. 14a . Alternatively, a detector ring 1401 may form an incomplete circle. In some embodiments, the detector ring 1401 may include two or more curved detector arrays. For example, each detector ring 1401 may be formed by one or more pairs of curved detector arrays spaced apart from each other by a distance. Each pair of curved detector arrays may be arranged in an opposing configuration. In some embodiments, the configurations of different detector rings 1401 in the detector 1400 may be the same or different.

As illustrated in FIG. 14b , a detector ring 1401 (e.g., the detector ring 1401-1) may include a plurality of crystal elements 411 and a plurality of photon-sensors 421. The crystal elements 411 may be arranged circumferentially along the peripheral direction of the detector ring 1401. Each crystal element 411 may include a proximal end and a distal end with respect to a central axis Z of the detector 1400 and extend along an extension direction from its distal end to its proximal end. The proximal end of a crystal element 411 may be close to the central axis and configured to receive radiation rays (e.g., gamma rays caused by annihilation events) from the scanning region. The distal end of a crystal element 411 may be far from the central axis and optically coupled with a photon-sensor 421 (shown as a darkened area in FIG. 14b ).

In some embodiments, a photon-sensor 421 may be optically coupled with one or more crystal elements 411 of a detector ring 1401. Different photon-sensors 421 may be coupled with the same number/count of or different numbers/counts of crystal elements 411. For example, each photon-sensor 421 may be coupled with two adjacent crystal elements 411 in a detector ring 1401 along the circumferential direction of the detector ring 1401. In some embodiments, the plurality of photon-sensors 421 may form a plurality of photon-sensor rows along the Z axis direction as illustrated in FIG. 14b . In some embodiments, a coincidence event detected by photon-sensors 421 of a same detector ring 1401 may be referred to as a direct coincidence, and the coincidence event may define a direct plane. A coincidence event detected by photon-sensors 421 of different rings 1401 may be referred to as a cross coincidence, and the coincidence event may define a cross plane. A direct plane may be parallel or substantially parallel to the X-Y plane illustrated in FIG. 14a and a cross plane may have a certain angle with the X-Y plane.

In some embodiments, the crystal elements 411 may form a plurality of crystal groups 1402 arranged along the Z axis. The crystal group 1402 may be similar to the crystal group 430, except for certain components or features. Each crystal group 1402 may include at least two crystal elements 411 that belong to at least two individual detector rings 1401. For example, as illustrated in FIG. 14b , a crystal element 411 e of the detector ring 1401-1 and a crystal element 411 f of the detector ring 1401-2 may form a crystal group. As another example, a crystal element 411 g of the detector ring 1401-3 and another crystal element 411 (not shown in FIG. 14b ) in an adjacent detector ring 1401 may form a crystal group.

Similar to the crystal group 430 illustrated in FIGS. 4 to 6 b and the description thereof, one or more first optical separators 412 and second optical separators 413 (not shown in FIGS. 14a and 14b ) may be used in and/or between the crystal groups 1402, in order to control the light transmission between and within the crystal groups 1402. For example, a first optical separator 412 of a first length may be disposed or located between two adjacent crystal groups 1402. A second optical separator 413 of a second length may be disposed or located between two adjacent crystal elements 411 of a crystal group 1402. The first length of the first optical separator may be greater than the second length of the second optical separator. As used herein, the length of an optical separator of two adjacent crystal groups 1402 may refer to its length along an extension direction (or the third direction) of at least one crystal element 411 of the two adjacent crystal groups 1402. More descriptions of the first optical separator 412 and the second optical separator 413 may be found elsewhere in the present disclosure (e.g., FIG. 4 and the descriptions thereof).

In some embodiments, to control the light transmission between two adjacent crystal elements 411 of a detector ring 1401, one or more third optical separators 1140 (not shown in FIGS. 14a and 14b ) may be applied. For example, a third optical separator 1140 (not shown) may be located between each pair of adjacent crystal elements 411 of each detector ring 1401. More descriptions of the third optical separator 1140 may be found elsewhere in the present disclosure (e.g., FIGS. 11a and 11b and the descriptions thereof).

It should be noted that the detector 1400 shown in FIGS. 14a and 14b are merely provided for the purposes of illustration, and not intended to limit the scope of the present disclosure. For persons having ordinary skills in the art, multiple variations and modifications may be made under the teachings of the present disclosure. However, those variations and modifications do not depart from the scope of the present disclosure. In some embodiments, a detector 1400 may include any number/count of detector rings 1401. For example, the detector 1400 may include 16, 32, 64, or 96 detector rings. In some embodiments, a crystal group 1402 may include any number/count of crystal elements 411 arranged along the Z axis direction. For example, the crystal elements 411 e, 411 f, and 411 g may form a crystal group.

FIG. 15 is a block diagram illustrating an exemplary computing device 140 according to some embodiments of the present disclosure. As shown in FIG. 15, the computing device 140 may include an acquisition module 1501 and a determination module 1502.

The acquisition module 1501 may be configured to obtain information used to determine the position of a photon gamma interaction in a crystal group. For example, the acquisition module 1501 may obtain output information of a plurality of photon-sensors optically coupled with the crystal group. As another example, the acquisition module 1501 may obtain a look-up table that records a relationship between depths of the photon gamma interaction and the output information of the photon-sensors. In some embodiments, the acquisition module 1501 may obtain information from one or more components of the imaging system 100, such as the PET imaging device 110, the storage device 150. Additionally or alternatively, the acquisition module 1501 may obtain information from an external source via the network 120.

The determination module 1502 may be configured to determine the position of a photon gamma interaction in a crystal group. For example, the determination module 1502 may determine a target crystal element in which the photon gamma interaction occurs in the crystal group. As another example, the determination module 1502 may determine the depth of the photon gamma interaction in the target crystal element. In some embodiments, the determination module 1502 may take an ICS phenomenon into consideration in the determination of the photon gamma interaction position. More descriptions regarding the determination of the photon gamma interaction position may be found elsewhere in the present disclosure. See, e.g., FIGS. 16 and 17 and relevant descriptions thereof.

It should be noted that the above description regarding the computing device 140 is merely provided for the purposes of illustration, and not intended to limit the scope of the present disclosure. For persons having ordinary skills in the art, multiple variations or modifications may be made under the teachings of the present disclosure. However, those variations and modifications do not depart from the scope of the present disclosure. For example, the computing device 140 may include a storage module configured to store data generated by the above-mentioned modules of the computing device 140. As another example, one or more modules may be integrated into a single module to perform the functions thereof. Merely by way of example, the acquisition module 1501 and the determination module 1502 may be integrated into a module to acquire and analyze information.

FIG. 16 is a flowchart illustrating an exemplary process for determining a position of a photon gamma interaction in a crystal group according to some embodiments of the present disclosure. In some embodiments, one or more operations of the process 1600 illustrated in FIG. 16 may be implemented in the imaging system 100 illustrated in FIG. 1. For example, the process 1600 illustrated in FIG. 16 may be stored in the storage device 150 in the form of instructions, and invoked and/or executed by the computing device 140.

In 1601, the acquisition module 1501 may obtain output information of a first photon-sensor and a second photon-sensor. The first photon-sensor and the second photon-sensor may be optically coupled with a crystal group (e.g., the crystal group 430, the crystal group 1402, or the crystal group 900) as described elsewhere in this disclosure. The crystal group may include a plurality of crystal elements. Each of the first and second photon-sensors may be optically coupled with one or more of the crystal elements. For example, the crystal group may include two crystal elements, each of which may be optically coupled with the first photon-sensor and the second photon-sensor, respectively.

When a photon gamma interaction occurs in the crystal group coupled with the first and second photon-sensors, it may excite one or more optical photons, which may in turn be detected by the first photon-sensor and/or the second photon-sensor. In response to the detected optical photons, the first and the second photon-sensors may output electrical signals, which are referred to as the output information herein. The output information may include first output information of the first photon-sensor and second output information of the second photon-sensor. In some embodiments, the first or the second output information may include a value of the energy detected by the corresponding first or second photon-sensor. Alternatively, the output information of the first or the second photon-sensor may be a parameter other than the energy value, such as a signal intensity, a pulse width. The determination module 1502 may determine the corresponding energy value based on the output information.

In 1602, the determination module 1502 may identify, in the crystal group, a target crystal element in which the photon gamma interaction occurs based on the output information. In some embodiments, the target crystal element in the crystal group may be determined by comparing the energy detected by the first photon-sensor and the second photon-sensor. The target crystal element may be the one whose corresponding photon-sensor detects the greatest energy. For example, if the output information shows that the first photon-sensor detects greater energy than the second photon-sensor, the crystal element(s) corresponding to the first photon-sensor may be regarded as the target crystal element. In some embodiments, the first or the second photon-sensor may correspond to a plurality of crystal elements, and it may be possible that the target crystal element accordingly may include a plurality of crystal elements.

In 1603, the determination module 1502 may determine, based on the output information, a depth of the photon gamma interaction within the target crystal element. The depth of the photon gamma interaction (or DOI) within the target crystal element may refer to a distance between the photon gamma interaction and the first end S1 of the target crystal element along the extension direction of the target crystal element. In some embodiments, the depth may be determined based on a ratio of the energy detected by the first photon-sensor to the energy detected by the second photon-sensor. For example, the depth d of the photon gamma interaction within the target crystal element may be determined according to Equation (1): d=LUT[E1/(E1+E2)]  (1), where E1 represents the energy detected by the first photon-sensor; E2 represents the energy detected by the second photon-sensor; and LUT represents an operation of looking up a lookup table. The lookup table may refer to a table that records a relationship between depths of photon gamma interactions in a target crystal element and values of E1/(E1+E2). In some embodiments, the lookup table may be determined based on a plurality of depths of photon gamma interactions and their corresponding values of E1/(E1+E2). The lookup table may be stored in a storage device (e.g., the storage device 150) of the imaging system 100. In the determination of the depth, the computing device 140 may retrieve the lookup table from the storage device and determine the depth d of the photon gamma interaction by consulting the lookup table.

It should be noted that the above description of the process 1600 is merely provided for the purpose of illustration, and not intended to limit the scope of the present disclosure. For persons having ordinary skills in the art, multiple variations and modifications may be made to the process 1600 under the teachings of the present disclosure. However, those variations and modifications do not depart from the scope of the present disclosure. In some embodiments, output information of two or more photon-sensors may be obtained in 1601. The two or more photon-sensors may be optically coupled with a crystal group (e.g., the crystal group 430, the crystal group 1402) as described elsewhere in this disclosure. The position of the photon gamma interaction may be determined based on the output information by performing operations 1602 and 1603. In some embodiments, as described in connection with FIGS. 9a and 9b , the DOI of a photon gamma interaction occurred within a crystal group (e.g., the crystal group 900) may be determined based on the time when the first photon-sensor and the second photon-sensor detected the corresponding photons.

FIG. 17 is a flowchart illustrating an exemplary process for determining a position of a photon gamma interaction according to some embodiments of the present disclosure. In some embodiments, one or more operations of the process 1700 illustrated in FIG. 17 may be implemented in the imaging system 100 illustrated in FIG. 1. For example, the process 1700 illustrated in FIG. 17 may be stored in the storage device 150 in the form of instructions, and invoked and/or executed by the computing device 140. In some embodiments, the process 1700 may be an example of the process 1600 when an ICS phenomenon is considered.

In 1701, the acquisition module 1501 may obtain output information of a plurality of photon-sensor groups. Each of the photon-sensor groups may include two or more photon-sensors and be optically coupled with a crystal group (e.g., the crystal group 430, the crystal group 1402) of a detector. The output information may include output information of the photon-sensor groups, and relate to a photon gamma interaction that occurs in the crystal groups.

In 1702, the determination module 1502 may determine, based on the output information, a plurality of candidate positions of the photon gamma interaction in the crystal groups. A candidate position may correspond to one of the plurality of crystal groups. A candidate position corresponding to a crystal group may include a candidate target crystal element in which the photon gamma interaction may have occurred and/or a candidate depth of the photon gamma interaction in the crystal group. In some embodiments, for each crystal group, the determination module 1502 may determine a position of the photon gamma interaction in the crystal group based on the output information of the corresponding photon-sensor group by implementing at least part of the process 1600. The determination module 1502 may then designate the position in each crystal group as one candidate position.

In 1703, the determination module 1502 may determine that an ICS occurs within the crystal groups based on the output information. In some embodiments, the determination module 1502 may determine whether the ICS occurs within the crystal groups based on the output information of each photon-sensor group and an energy of an annihilation photon involved in the photon gamma interaction. For example, if a sum of energy detected by one or more of the photon-sensor groups is equal to the energy of the annihilation photon, the determination module 1502 may determine that an ICS occurs within the plurality of crystal groups.

In 1704, the determination module 1502 may designate, among the plurality of candidate positions, the candidate position with the smallest candidate depth as a position of the photon gamma interaction. Because back scatter rarely occurs, the candidate position with the smallest candidate depth may be closest to the scanned object and correspond to a crystal element from which the annihilation photon initially enters, and therefore it may be deemed as the position of the photon gamma interaction.

It should be noted that the above description of the process 1700 is merely provided for the purpose of illustration, and not intended to limit the scope of the present disclosure. For persons having ordinary skills in the art, multiple variations and modifications may be made to the process 1700 under the teachings of the present disclosure. However, those variations and modifications do not depart from the scope of the present disclosure. For example, operations 1702 and 1703 may be performed simultaneously or operation 1703 may be performed before operation 1702.

Having thus described the basic concepts, it may be rather apparent to those skilled in the art after reading this detailed disclosure that the foregoing detailed disclosure is intended to be presented by way of example only and is not limiting. Various alterations, improvements, and modifications may occur and are intended to those skilled in the art, though not expressly stated herein. These alterations, improvements, and modifications are intended to be suggested by this disclosure and are within the spirit and scope of the exemplary embodiments of this disclosure.

Moreover, certain terminology has been used to describe embodiments of the present disclosure. For example, the terms “one embodiment,” “an embodiment,” and/or “some embodiments” mean that a particular feature, structure or characteristic described in connection with the embodiment is included in at least one embodiment of the present disclosure. Therefore, it is emphasized and should be appreciated that two or more references to “an embodiment” or “one embodiment” or “an alternative embodiment” in various portions of this specification are not necessarily all referring to the same embodiment. Furthermore, the particular features, structures or characteristics may be combined as suitable in one or more embodiments of the present disclosure.

Further, it will be appreciated by one skilled in the art, aspects of the present disclosure may be illustrated and described herein in any of a number of patentable classes or context including any new and useful process, machine, manufacture, or composition of matter, or any new and useful improvement thereof. Accordingly, aspects of the present disclosure may be implemented entirely hardware, entirely software (including firmware, resident software, micro-code, etc.) or combining software and hardware implementation that may all generally be referred to herein as a “unit,” “module,” or “system.” Furthermore, aspects of the present disclosure may take the form of a computer program product embodied in one or more computer readable media having computer readable program code embodied thereon.

A computer readable signal medium may include a propagated data signal with computer readable program code embodied therein, for example, in baseband or as part of a carrier wave. Such a propagated signal may take any of a variety of forms, including electromagnetic, optical, or the like, or any suitable combination thereof. A computer readable signal medium may be any computer readable medium that is not a computer readable storage medium and that may communicate, propagate, or transport a program for use by or in connection with an instruction execution system, apparatus, or device. Program code embodied on a computer readable signal medium may be transmitted using any appropriate medium, including wireless, wireline, optical fiber cable, RF, or the like, or any suitable combination of the foregoing.

Computer program code for carrying out operations for aspects of the present disclosure may be written in any combination of one or more programming languages, including an object oriented programming language such as JAVA, SCALA, SMALLTALK, EIFFEL, JADE, EMERALD, C++, C#, VB. NET, PYTHON or the like, conventional procedural programming languages, such as the “C” programming language, Visual Basic, Fortran 2013, PERL, COBOL 2012, PHP, ABAP, dynamic programming languages such as PYTHON, RUBY, and GROOVY, or other programming languages. The program code may execute entirely on the user's computer, partly on the user's computer, as a stand-alone software package, partly on the user's computer and partly on a remote computer or entirely on the remote computer or server. In the latter scenario, the remote computer may be connected to the user's computer through any type of network, including a local area network (LAN) or a wide area network (WAN), or the connection may be made to an external computer (for example, through the Internet using an Internet Service Provider) or in a cloud computing environment or offered as a service such as a Software as a Service (SaaS).

Furthermore, the recited order of processing elements or sequences, or the use of numbers, letters, or other designations, therefore, is not intended to limit the claimed processes and methods to any order except as may be specified in the claims. Although the above disclosure discusses through various examples what is currently considered to be a variety of useful embodiments of the disclosure, it is to be understood that such detail is solely for that purpose and that the appended claims are not limited to the disclosed embodiments, but, on the contrary, are intended to cover modifications and equivalent arrangements that are within the spirit and scope of the disclosed embodiments. For example, although the implementation of various components described above may be embodied in a hardware device, it may also be implemented as a software only solution, for example, an installation on an existing server or mobile device.

Similarly, it should be appreciated that in the foregoing description of embodiments of the present disclosure, various features are sometimes grouped in a single embodiment, figure, or description thereof for the purpose of streamlining the disclosure aiding in the understanding of one or more of the various inventive embodiments. This method of disclosure, however, is not to be interpreted as reflecting an intention that the claimed subject matter requires more features than are expressly recited in each claim. Rather, inventive embodiments lie in less than all features of a single foregoing disclosed embodiment.

In some embodiments, the numbers expressing quantities or properties used to describe and claim certain embodiments of the application are to be understood as being modified in some instances by the term “about,” “approximately,” or “substantially.” For example, “about,” “approximately,” or “substantially” may indicate ±20% variation of the value it describes, unless otherwise stated. Accordingly, in some embodiments, the numerical parameters set forth in the written description and attached claims are approximations that may vary depending upon the desired properties sought to be obtained by a particular embodiment. In some embodiments, the numerical parameters should be construed in light of the number of reported significant digits and by applying ordinary rounding techniques. Notwithstanding that the numerical ranges and parameters setting forth the broad scope of some embodiments of the application are approximations, the numerical values set forth in the specific examples are reported as precisely as practicable.

Each of the patents, patent applications, publications of patent applications, and other material, such as articles, books, specifications, publications, documents, things, and/or the like, referenced herein is hereby incorporated herein by this reference in its entirety for all purposes, excepting any prosecution file history associated with same, any of same that is inconsistent with or in conflict with the present document, or any of same that may have a limiting affect as to the broadest scope of the claims now or later associated with the present document. By way of example, should there be any inconsistency or conflict between the descriptions, definition, and/or the use of a term associated with any of the incorporated material and that associated with the present document, the description, definition, and/or the use of the term in the present document shall prevail.

In closing, it is to be understood that the embodiments of the application disclosed herein are illustrative of the principles of the embodiments of the application. Other modifications that may be employed may be within the scope of the application. Thus, by way of example, but not of limitation, alternative configurations of the embodiments of the application may be utilized in accordance with the teachings herein. Accordingly, embodiments of the present application are not limited to that precisely as shown and described. 

What is claimed is:
 1. A positron emission tomography (PET) detector being configured to identify a depth of a photon gamma interaction, comprising: a crystal array including a plurality of crystal elements, the plurality of crystal elements being arranged along a first direction and a second direction so as to define a plurality of crystal groups along the first direction, each of the plurality of crystal groups including at least two crystal elements of the plurality of crystal elements, each of the plurality of crystal elements including a first end and a second end and extending along a third direction from the first end to the second end, and a photon-sensor array optically coupled with the crystal array, wherein at least one pair of neighboring crystal groups of the plurality of crystal groups include: a first optical separator of a first length located between the crystal groups of the at least one pair of neighboring crystal groups, the first length being along the third direction; and a second optical separator of a second length located between two neighboring crystal elements of a crystal group of the at least one pair of neighboring crystal groups, the second length being along the third direction, wherein the first length of the first optical separator is equal to a length of at least one of the two neighboring crystal elements between which the first optical separator is located, and the second length of the second optical separator is shorter than a length of at least one of the two neighboring crystal elements between which the second optical separator is located.
 2. The PET detector of claim 1, wherein the photon-sensor array forms a single-end read-out structure, and the photon-sensor array includes a plurality of photon-sensors configured to receive photons emitted from the first ends of the plurality of crystal elements.
 3. The PET detector of claim 2, wherein each photon-sensor of the photon-sensor array is optically coupled with one or more crystal elements of the plurality of crystal elements.
 4. The PET detector of claim 1, wherein: the detector further comprises one or more third optical separators, each of the one or more third optical separators being located between two neighboring crystal elements along the second direction.
 5. The PET detector of claim 4, wherein at least one of the first optical separator, the second optical separator, or the one or more third optical separators includes at least one of a reflective film, a reflective foil, or a reflective coating.
 6. The PET detector of claim 1, wherein: the second length of the second optical separator is equal to or greater than a half of a length of at least one of the two neighboring crystal elements between which the second optical separator is located, the length of the crystal element being along the third direction.
 7. The PET detector of claim 1, wherein: at least one of the first optical separator or second optical separator extends, along the third direction, from the first end of at least one of two neighboring crystal elements between which the at least one of the first or second optical separator is located.
 8. The PET detector of claim 1, wherein in at least one crystal group of the plurality of crystal groups, the second ends of the at least two crystal elements are integrated into a single end.
 9. The PET detector of claim 1, wherein the plurality of crystal elements forms a plurality of detector rings arranged along an axial direction of the detector.
 10. A method for determining photon gamma interaction positions implemented on a computing machine having one or more processors and one or more storage devices, the method comprising: obtaining output information of at least two photon-sensors, the at least two photon-sensors being optically single-end-coupled with a crystal group of a PET detector according to claim 1; and determining, based on the output information, a position of the photon gamma interaction within the crystal group.
 11. The method of claim 10, wherein the determining the position of the photon gamma interaction within the crystal group comprises: identifying, in the crystal group, a target crystal element in which the photon gamma interaction occurs based on the output information.
 12. The method of claim 11, further comprising: determining, based on the output information, a depth of the photon gamma interaction within the target crystal element.
 13. The method of claim 10, wherein the output information of the at least two photon-sensors comprises an energy detected by each of the at least two photon-sensors, and the determining the position of the photon gamma interaction within the crystal group comprises: determining, based on the energy detected by each of the at least two photon-sensors, a total energy detected by the at least two photon-sensors; and determining, based on the energy detected by each of the at least two photon-sensors and the total energy, the position of the photon gamma interaction within the crystal group.
 14. The method of claim 10, wherein the PET detector including a plurality of crystal groups, the method further comprising: determining, based on the output information, a plurality of candidate positions of the photon gamma interaction in the plurality of crystal groups, each of the plurality of candidate positions corresponding to one of the plurality of crystal groups and including a candidate depth of the photon gamma interaction within the corresponding crystal group; determining, based on the output information, that an inter crystal scatter (ICS) occurs within the plurality of crystal groups; and designating, among the plurality of candidate positions, the candidate position with the smallest candidate depth as a position of the photon gamma interaction.
 15. A positron emission tomography (PET) detector being configured to identify a depth of a photon gamma interaction, comprising: a crystal array including a plurality of crystal elements, the plurality of crystal elements being arranged along a first direction and a second direction so as to define a plurality of crystal groups along the first direction, each of the plurality of crystal groups including at least two crystal elements of the plurality of crystal elements, each of the plurality of crystal elements including a first end and a second end and extending along a third direction from the first end to the second end, and a single-end read-out structure including a photon-sensor array optically coupled with the crystal array, wherein at least one crystal group of the plurality of crystal groups includes: an optical window configured to allow a light transmission between the at least two crystal elements of the at least one crystal group, so that a photon excited by an photon gamma interaction in a first crystal element of the at least one crystal group can travel into a second crystal element of the at least one crystal group through the second end of the first crystal element, the optical window, and the second end of the second crystal element.
 16. The PET detector of claim 15, wherein the optical window of the at least one crystal group includes: for each of the at least two crystal elements of the at least one crystal group, an optical separator mounted on each side surface of the crystal element that faces an neighboring crystal element of the crystal element along the first direction, a length of the optical separator equal to a length of at least one of the crystal element or the neighboring crystal element, the length of the optical separator and the length of the at least one of the crystal element or the neighboring crystal element being along the third direction; a light transmission medium covering the second ends of the at least two crystal elements of the at least one crystal group, each side surface of the light transmission medium that faces a neighboring crystal group of the at least one crystal group being coated with a light reflective material.
 17. The PET detector of claim 16, wherein the light transmission medium is glass.
 18. The PET detector of claim 15, wherein the photon-sensor array includes a plurality of photon-sensors configured to receive photons emitted from the first ends of the plurality of crystal elements.
 19. The PET detector of claim 15, wherein the optical window of the at least one crystal group forms as below: an optical separator, extending from the first end of one of the plurality of crystal elements to the second end of the one of the plurality of crystal elements, is arranged between the at least two crystal elements of the at least one crystal group, and the length of the optical separator is less than a length of at least one of the at least two crystal elements. 